Previous studies by our laboratory established a rat model of neuropathic pain which
displayed long-lasting heat hyperalgesia and mechanical allodynia that are sympathetically
maintained. The present study was undertaken to extend our earlier findings by examining
additional behavioral signs of ongoing pain and cold allodynia in our animal model and
testing their sympathetic dependency. Neuropathic surgery was done by tightly ligating the
L5 and L6 segmental spinal nerves of rats unilaterally. In addition to the behavioral signs of …