The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens
AM Pullen, P Marrack, JW Kappler - Nature, 1988 - nature.com
AM Pullen, P Marrack, JW Kappler
Nature, 1988•nature.comT cells with Vβ3+ αβ receptors are deleted by self-tolerance in mice with particular major
histocompatibility complex/self-antigen combinations. This also occurs for other Vβ
elements. Polymorphisms in the major histocompatibility complex and/or the self-antigens
that cause massive deletion of T cells using particular Vβ elements may be maintained by
the need to balance the advantage of a diverse T-cell repertoire against the potential
involvement of those elements in autoimmune disease.
histocompatibility complex/self-antigen combinations. This also occurs for other Vβ
elements. Polymorphisms in the major histocompatibility complex and/or the self-antigens
that cause massive deletion of T cells using particular Vβ elements may be maintained by
the need to balance the advantage of a diverse T-cell repertoire against the potential
involvement of those elements in autoimmune disease.
Abstract
T cells with Vβ3+αβ receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other Vβ elements. Polymorphisms in the major histocompatibility complex and / or the self-antigens that cause massive deletion of T cells using particular Vβ elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease.
nature.com