A hypothesis on the pathogenesis of rheumatoid and other non-specific synovitides. IV A. The possible intermediate role of local hypoxia and metabolic alterations
J Ahlqvist - Medical Hypotheses, 1984 - Elsevier
According to the original hypothesis, synovial tissue (ST) oedema and synovial fluid (SF)
volume increase contribute to local hypoxia and metabolic alterations and to inflammation (A
1). Studies on biochemical mechanisms (A 2) in synovitides show that the SF volume
correlates to SF hypoxia that correlates to lactate increase, acidosis and to some decrease
in glucose. Normal ST produces lactate by glycolytic and pentose phosphate pathway
activity, both, as well as the normally low oxygen utilization, being increased in synovitides …
volume increase contribute to local hypoxia and metabolic alterations and to inflammation (A
1). Studies on biochemical mechanisms (A 2) in synovitides show that the SF volume
correlates to SF hypoxia that correlates to lactate increase, acidosis and to some decrease
in glucose. Normal ST produces lactate by glycolytic and pentose phosphate pathway
activity, both, as well as the normally low oxygen utilization, being increased in synovitides …
