[HTML][HTML] Functional competition between poly (ADP-ribose) polymerase and its 24-kDa apoptotic fragment in DNA repair and transcription
TMC Yung, MS Satoh - Journal of Biological Chemistry, 2001 - ASBMB
Poly (ADP-ribose) polymerase is a 113-kDa nuclear enzyme that binds to both damaged
DNA and to RNA associated with actively transcribed regions of chromatin. Binding of poly
(ADP-ribose) polymerase to DNA lesions activates it, catalyzing the covalent addition of
multiple ADP-ribose polymers to the enzyme (automodification). During apoptosis, poly
(ADP-ribose) polymerase is cleaved by caspase-3, resulting in the formation of an N-
terminal 24-kDa fragment, containing the DNA binding domain, and a C-terminal 89-kDa …
DNA and to RNA associated with actively transcribed regions of chromatin. Binding of poly
(ADP-ribose) polymerase to DNA lesions activates it, catalyzing the covalent addition of
multiple ADP-ribose polymers to the enzyme (automodification). During apoptosis, poly
(ADP-ribose) polymerase is cleaved by caspase-3, resulting in the formation of an N-
terminal 24-kDa fragment, containing the DNA binding domain, and a C-terminal 89-kDa …
