Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administration
DG Brockstedt, GM Podsakoff, L Fong, G Kurtzman… - Clinical …, 1999 - Elsevier
Recombinant adeno-associated virus (rAAV) is a replication-defective parvovirus which is
being explored as a vector for gene therapy because of its broad host range, excellent safety
profile, and durable transgene expression in infected hosts. rAAV has also been reported by
several groups to induce little or no immune response to its encoded transgene products. In
this study we examined the immunogenicity of rAAV by studying the immune response of
C57BL/6 mice to a single dose of rAAV-encoding ovalbumin (AAV-Ova) administered by a …
being explored as a vector for gene therapy because of its broad host range, excellent safety
profile, and durable transgene expression in infected hosts. rAAV has also been reported by
several groups to induce little or no immune response to its encoded transgene products. In
this study we examined the immunogenicity of rAAV by studying the immune response of
C57BL/6 mice to a single dose of rAAV-encoding ovalbumin (AAV-Ova) administered by a …