Eicosanoid biosynthesis in human cardiovascular disease
GA Fitzgerald, F Catella, JA Oates - Human pathology, 1987 - Elsevier
Thromboxane A 2, the predominant cyclooxygenase product in platelets, is a potent platelet
agonist and vasoconstrictor in vitro. Prostacyclin, the major product of vascular endothelium,
has opposite effects on platelet function and vascular tone. These properties prompted the
hypothesis that a “balance” between these compounds regulated interactions between
platelets and the vessel wall in vivo. Although this possibility has been addressed
extensively through experiments in vitro, clinical investigations commonly have been …
agonist and vasoconstrictor in vitro. Prostacyclin, the major product of vascular endothelium,
has opposite effects on platelet function and vascular tone. These properties prompted the
hypothesis that a “balance” between these compounds regulated interactions between
platelets and the vessel wall in vivo. Although this possibility has been addressed
extensively through experiments in vitro, clinical investigations commonly have been …