[HTML][HTML] Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction …
M Ishigami, DK Swertfeger, NA Granholm… - Journal of Biological …, 1998 - ASBMB
The anti-atherogenic effects of apolipoprotein (apo) E have been attributed to its ability to
reduce plasma cholesterol level and to limit foam cell formation. The purpose of this study
was to ascertain if apoE also may have cytostatic functions that could attenuate vascular
occlusive diseases. Purified apoE inhibited smooth muscle cell migration directed to platelet-
derived growth factor (PDGF) or oxidized LDL (oxLDL)(p< 0.0001). The purified apoE also
suppressed PDGF-and oxLDL-induced smooth muscle cell proliferation (p< 0.001). These …
reduce plasma cholesterol level and to limit foam cell formation. The purpose of this study
was to ascertain if apoE also may have cytostatic functions that could attenuate vascular
occlusive diseases. Purified apoE inhibited smooth muscle cell migration directed to platelet-
derived growth factor (PDGF) or oxidized LDL (oxLDL)(p< 0.0001). The purified apoE also
suppressed PDGF-and oxLDL-induced smooth muscle cell proliferation (p< 0.001). These …