[HTML][HTML] Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial …
T Kimura, K Sato, A Kuwabara, H Tomura… - Journal of Biological …, 2001 - ASBMB
Sphingosine 1-phosphate (S1P), a novel lipid mediator, is concentrated in the fraction of
lipoproteins that include high density lipoprotein (HDL) and low density lipoprotein (LDL) in
human plasma. Here, we show that oxidation of LDL resulted in a marked reduction in the
S1P level in association with a marked accumulation of lysophosphatidylcholine (LPC). We
therefore investigated the role of the lipoprotein-associated lipids especially S1P in the
lipoprotein-induced cytoprotective or cytotoxic actions in human umbilical vein endothelial …
lipoproteins that include high density lipoprotein (HDL) and low density lipoprotein (LDL) in
human plasma. Here, we show that oxidation of LDL resulted in a marked reduction in the
S1P level in association with a marked accumulation of lysophosphatidylcholine (LPC). We
therefore investigated the role of the lipoprotein-associated lipids especially S1P in the
lipoprotein-induced cytoprotective or cytotoxic actions in human umbilical vein endothelial …