[HTML][HTML] Phosphoinositide 3-Kinase γ and p85/Phosphoinositide 3-Kinase in Platelets: RELATIVE ACTIVATION BY THROMBIN RECEPTOR OR β-PHORBOL …
J Zhang, J Zhang, SJ Shattil, MC Cunningham… - Journal of Biological …, 1996 - ASBMB
Platelets exposed to thrombin or thrombin receptor agonist peptide (SFLLRN) activate
phospholipase C and protein kinase C (PKC), and accumulate 3-phosphorylated
phosphoinositides (3-PPI) as a function of the activation and relocalization of two
cytoskeletally-associated phosphoinositide 3-kinases (PI 3-K): p85/PI 3-K and PI 3-Kγ. We
now report that exposure of platelets to PKC-activating β-phorbol myristate acetate (βPMA)
does not stimulate PI 3-Kγ, but rather stimulates p85/PI 3-K, which associates with the …
phospholipase C and protein kinase C (PKC), and accumulate 3-phosphorylated
phosphoinositides (3-PPI) as a function of the activation and relocalization of two
cytoskeletally-associated phosphoinositide 3-kinases (PI 3-K): p85/PI 3-K and PI 3-Kγ. We
now report that exposure of platelets to PKC-activating β-phorbol myristate acetate (βPMA)
does not stimulate PI 3-Kγ, but rather stimulates p85/PI 3-K, which associates with the …