[HTML][HTML] Dual regulation of platelet protein kinase B
C Kroner, K Eybrechts, JWN Akkerman - Journal of Biological Chemistry, 2000 - ASBMB
Protein kinase B (PKB) is a serine/threonine kinase that is activated by growth hormones
and implicated in prevention of apoptosis, glycogen metabolism, and glucose uptake. A key
enzyme in PKB activation is phosphatidylinositide 3-kinase (PI-3K), which triggers the dual
phosphorylation of PKB by phosphatidylinositol-dependent kinases (PDKs). Here we report
that the major PKB subtype in platelets is PKBα, which is activated by phosphorylation of Thr
308 and Ser 473 and has a constitutively phosphorylated Thr 450 that does not contribute to …
and implicated in prevention of apoptosis, glycogen metabolism, and glucose uptake. A key
enzyme in PKB activation is phosphatidylinositide 3-kinase (PI-3K), which triggers the dual
phosphorylation of PKB by phosphatidylinositol-dependent kinases (PDKs). Here we report
that the major PKB subtype in platelets is PKBα, which is activated by phosphorylation of Thr
308 and Ser 473 and has a constitutively phosphorylated Thr 450 that does not contribute to …