Publisher Summary This chapter discusses the mechanisms and roles of apoptosis in
pathology. Necrosis differs from apoptosis in structure, mechanism, and sequelae.
Structurally, necrotic cells show critically damaged organelles, ruptured plasma membranes,
and dispersal of cytoplasmic elements into the extracellular space. The mechanisms are
various, but do not depend upon continuing synthetic activity. There is no evidence that
specific signaling pathways are involved. There is breakdown of membrane homeostasis …