Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene
F Galland, A Karamysheva, MG Mattei, O Rosnet… - Genomics, 1992 - Elsevier
F Galland, A Karamysheva, MG Mattei, O Rosnet, S Marchetto, D Birnbaum
Genomics, 1992•ElsevierA new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by
screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid
sequence of the intracellular region of the molecule showed that it was strongly related to
the FLT1 and KDR FLK 1 gene products and to a lesser degree to members of the class III
RTKs FMS CSF 1 R, PDGFRA B, KIT, and FLT3. The gene was named FLT4 Cosmid clones
of the mouse Flt4 gene were isolated. The human gene was localized to bands q34–q35 of …
screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid
sequence of the intracellular region of the molecule showed that it was strongly related to
the FLT1 and KDR FLK 1 gene products and to a lesser degree to members of the class III
RTKs FMS CSF 1 R, PDGFRA B, KIT, and FLT3. The gene was named FLT4 Cosmid clones
of the mouse Flt4 gene were isolated. The human gene was localized to bands q34–q35 of …
A new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid sequence of the intracellular region of the molecule showed that it was strongly related to the FLT1 and KDR FLK 1 gene products and to a lesser degree to members of the class III RTKs FMS CSF 1 R, PDGFRA B, KIT, and FLT3. The gene was named FLT4 Cosmid clones of the mouse Flt4 gene were isolated. The human gene was localized to bands q34–q35 of chromosome 5, ie, slightly telomeric to the CSF 1 R PDGFRB tandem of genes, and the mouse homolog to chromosome 11, region A5-B1.
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