Sphingosine kinase: a mediator of vital cellular functions
A Olivera, S Spiegel - Prostaglandins & other lipid mediators, 2001 - Elsevier
Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular
second messenger regulating calcium mobilization, and cell growth and survival. Moreover,
the dynamic balance between levels of the sphingolipids metabolites, ceramide and SPP,
and consequent regulation of opposing signaling pathways, is an important factor that
determines whether a cell survives or dies. SPP has also recently been shown to be the
ligand for the EDG-1 family of G protein-coupled receptors, which now includes EDG-1,-3,-5 …
second messenger regulating calcium mobilization, and cell growth and survival. Moreover,
the dynamic balance between levels of the sphingolipids metabolites, ceramide and SPP,
and consequent regulation of opposing signaling pathways, is an important factor that
determines whether a cell survives or dies. SPP has also recently been shown to be the
ligand for the EDG-1 family of G protein-coupled receptors, which now includes EDG-1,-3,-5 …
