[HTML][HTML] Differential targeting of β-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae: a mechanism to functionally regulate the cAMP …
VO Rybin, X Xu, MP Lisanti, SF Steinberg - Journal of Biological Chemistry, 2000 - ASBMB
Differential modes for β 1-and β 2-adrenergic receptor (AR) regulation of adenylyl cyclase in
cardiomyocytes is most consistent with spatial regulation in microdomains of the plasma
membrane. This study examines whether caveolae represent specialized subdomains that
concentrate and organize these moieties in cardiomyocytes. Caveolae from quiescent rat
ventricular cardiomyocytes are highly enriched in β 2-ARs, Gα i, protein kinase A RIIα
subunits, caveolin-3, and flotillins (caveolin functional homologues); β 1-ARs, m 2 …
cardiomyocytes is most consistent with spatial regulation in microdomains of the plasma
membrane. This study examines whether caveolae represent specialized subdomains that
concentrate and organize these moieties in cardiomyocytes. Caveolae from quiescent rat
ventricular cardiomyocytes are highly enriched in β 2-ARs, Gα i, protein kinase A RIIα
subunits, caveolin-3, and flotillins (caveolin functional homologues); β 1-ARs, m 2 …