Brushite may play an important regulatory role in the formation of calcium-containing renal
stones. The urinary environment from patients with hypercalciuric nephrolithiasis is typically
supersaturated and shows an increased propensity for the spontaneous nucleation of
brushite. Brushite has been identified in “stone-forming” urine and in stones. This crystalline
phase may undergo phase transformation to hydroxyapatite or cause heterogeneous
nucleation or epitaxial growth of calcium oxalate. Thus, brushite may also participate in the …