Accumulating experimental evidence supports the proposal that many of the changes which
occur during aging are a consequence of oxidative damage. Reactive oxygen species react
with all three of the major cellular macromolecules, nucleic acids, lipids, and proteins. This
minireview focuses on proteins as targets of oxidizing species during aging. Many of the
reactions mediated by these oxidizing species result in the introduction of carbonyl groups
into proteins. The steady-state level of carbonyl-bearing proteins increases exponentially …