New DNA adducts of crotonaldehyde and acetaldehyde
SS Hecht, EJ McIntee, M Wang - Toxicology, 2001 - Elsevier
This paper summarizes our recent studies on adducts produced in the reactions of the
carcinogens crotonaldehyde (2-butenal) and acetaldehyde with deoxyguanosine (dG) and
DNA. Human exposure to these carcinogens can be considerable, from both exogenous
and endogenous sources. Crotonaldehyde reacts with DNA to form Michael addition
products, a pathway that has been well described. We describe a second major pathway, in
which 3-hydroxybutanal, formed by addition of H2O to crotonaldehyde, reacts with DNA to …
carcinogens crotonaldehyde (2-butenal) and acetaldehyde with deoxyguanosine (dG) and
DNA. Human exposure to these carcinogens can be considerable, from both exogenous
and endogenous sources. Crotonaldehyde reacts with DNA to form Michael addition
products, a pathway that has been well described. We describe a second major pathway, in
which 3-hydroxybutanal, formed by addition of H2O to crotonaldehyde, reacts with DNA to …
