Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
D Wang, DA Kreutzer, JM Essigmann - Mutation Research/Fundamental …, 1998 - Elsevier
Oxidative DNA damage has been implicated in mutagenesis, carcinogenesis and aging.
Endogenous cellular processes such as aerobic metabolism generate reactive oxygen
species (ROS) that interact with DNA to form dozens of DNA lesions. If unrepaired, these
lesions can exert a number of deleterious effects including the induction of mutations. In an
effort to understand the genetic consequences of cellular oxidative damage, many
laboratories have determined the patterns of mutations generated by the interaction of ROS …
Endogenous cellular processes such as aerobic metabolism generate reactive oxygen
species (ROS) that interact with DNA to form dozens of DNA lesions. If unrepaired, these
lesions can exert a number of deleterious effects including the induction of mutations. In an
effort to understand the genetic consequences of cellular oxidative damage, many
laboratories have determined the patterns of mutations generated by the interaction of ROS …
