[HTML][HTML] IκB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal
C Ji, KR Kozak, LJ Marnett - Journal of Biological Chemistry, 2001 - ASBMB
In unstimulated cells, transcription factor NF-κB is retained in the cytoplasm by interaction
with the inhibitory protein, IκBα. Appropriate cellular stimuli inactivate IκBα by
phosphorylation, ubiquination, and proteolytic degradation, which allows NF-κB to
translocate to the nucleus and modulate gene expression. 4-Hydroxy-2-nonenal (HNE), a
major lipid peroxidation product, inhibits activation of NF-κB in the human colorectal
carcinoma cell line (RKO) and human lung carcinoma cell line (H1299). Pretreatment of …
with the inhibitory protein, IκBα. Appropriate cellular stimuli inactivate IκBα by
phosphorylation, ubiquination, and proteolytic degradation, which allows NF-κB to
translocate to the nucleus and modulate gene expression. 4-Hydroxy-2-nonenal (HNE), a
major lipid peroxidation product, inhibits activation of NF-κB in the human colorectal
carcinoma cell line (RKO) and human lung carcinoma cell line (H1299). Pretreatment of …
