[HTML][HTML] Immunological adjuvants promote activated T cell survival via induction of Bcl-3
Nature immunology, 2001•nature.com
Injection of soluble protein antigen into animals causes abortive proliferation of the
responding T cells. Immunological adjuvants boost T cell responses at least in part by
increasing the survival of activated T cells during and after the initial proliferative phase of
their clonal expansion. To understand how adjuvants promote T cell survival, we used gene
microarrays to analyze gene expression in T cells activated either with antigen alone or in
the presence of two different adjuvants. Among the genes whose expression was increased …
responding T cells. Immunological adjuvants boost T cell responses at least in part by
increasing the survival of activated T cells during and after the initial proliferative phase of
their clonal expansion. To understand how adjuvants promote T cell survival, we used gene
microarrays to analyze gene expression in T cells activated either with antigen alone or in
the presence of two different adjuvants. Among the genes whose expression was increased …
Abstract
Injection of soluble protein antigen into animals causes abortive proliferation of the responding T cells. Immunological adjuvants boost T cell responses at least in part by increasing the survival of activated T cells during and after the initial proliferative phase of their clonal expansion. To understand how adjuvants promote T cell survival, we used gene microarrays to analyze gene expression in T cells activated either with antigen alone or in the presence of two different adjuvants. Among the genes whose expression was increased by both adjuvants was the IκB family member Bcl-3. Retroviral infection experiments showed that expression of Bcl-3 increased survival of activated T cells in vitro and in vivo. Adjuvants may therefore improve survival of activated T cells via induction of Bcl-3.
nature.com
