A single injection of Staphylococcus aureus enterotoxin B reduces autoimmunity in MRL/lpr mice
JA Gonzalo, R Tarazona, HJ Schuurman… - Clinical immunology and …, 1994 - Elsevier
MRL/Mp-lpr/lpr (MRL/lpr) mice carry a mutation in the Fas gene whose product is involved in
the regulation of lymphocyte apoptosis. This mutation is associated with the lpr
phenomenon, ie, a massive expansion of phenotypically abnormal CD4-CD8-cells (" double
negative," DN) α/β T cells (lpr cells) that becomes manifest at 3-4 months of age. As in
normal mice, intravenous SEB injection into 2-or 6-month-old female MRL/lpr mice causes a
transient expansion of SEB-reactive Vβ8+ T cells, followed by a deletion of this subset. In …
the regulation of lymphocyte apoptosis. This mutation is associated with the lpr
phenomenon, ie, a massive expansion of phenotypically abnormal CD4-CD8-cells (" double
negative," DN) α/β T cells (lpr cells) that becomes manifest at 3-4 months of age. As in
normal mice, intravenous SEB injection into 2-or 6-month-old female MRL/lpr mice causes a
transient expansion of SEB-reactive Vβ8+ T cells, followed by a deletion of this subset. In …
