[HTML][HTML] Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression
MKA Bauer, M Vogt, M Los, J Siegel… - Journal of Biological …, 1998 - ASBMB
Activation-induced cell death of T lymphocytes requires the inducible expression of CD95
(APO-1/Fas) ligand, which triggers apoptosis in CD95-bearing target cells by an autocrine or
paracrine mechanism. Although execution of the CD95 death pathway is largely
independent of reactive oxygen intermediates, activation-induced cell death is blocked by a
variety of antioxidants. In the present study, we investigated the involvement of redox
processes in the regulation of CD95 ligand (CD95L) expression in Jurkat T cells. We show …
(APO-1/Fas) ligand, which triggers apoptosis in CD95-bearing target cells by an autocrine or
paracrine mechanism. Although execution of the CD95 death pathway is largely
independent of reactive oxygen intermediates, activation-induced cell death is blocked by a
variety of antioxidants. In the present study, we investigated the involvement of redox
processes in the regulation of CD95 ligand (CD95L) expression in Jurkat T cells. We show …
