[HTML][HTML] Does artemis end the hunt for the hairpin-opening activity in V (D) J recombination?
MS Schlissel - Cell, 2002 - cell.com
Cell, 2002•cell.com
When complexed with the catalytic subunit of DNA-dependent protein kinase (DNA-PK cs),
the recently discovered dsDNA break repair protein named Artemis acquires the ability to
open hairpin DNA molecules in vitro. Both genetic and biochemical data point toward a
physiological role for this complex as the elusive hairpin-opening activity in V (D) J
recombination.
the recently discovered dsDNA break repair protein named Artemis acquires the ability to
open hairpin DNA molecules in vitro. Both genetic and biochemical data point toward a
physiological role for this complex as the elusive hairpin-opening activity in V (D) J
recombination.
Abstract
When complexed with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), the recently discovered dsDNA break repair protein named Artemis acquires the ability to open hairpin DNA molecules in vitro. Both genetic and biochemical data point toward a physiological role for this complex as the elusive hairpin-opening activity in V(D)J recombination.
cell.com
