AP-2β represses D1A dopamine receptor gene transcription in Neuro2a cells
S Takeuchi, I Imafuku, M Waragai, C Roth… - Molecular brain …, 1999 - Elsevier
Expression of the D1A dopamine receptor in brain is restricted to specific neuronal
populations. To investigate the mechanism of this selective expression, we localized a
silencer upstream of the human D1A gene and identified its binding transcription factor in
the D1A-negative neural cell line Neuro2a. Using deletion CAT analysis, we narrowed this
silencer to the region between nucleotides− 561 and− 532 relative to the CAP site. This 30-
bp region, designated D1AS1, contains a sequence homologous to the AP-2 binding site …
populations. To investigate the mechanism of this selective expression, we localized a
silencer upstream of the human D1A gene and identified its binding transcription factor in
the D1A-negative neural cell line Neuro2a. Using deletion CAT analysis, we narrowed this
silencer to the region between nucleotides− 561 and− 532 relative to the CAP site. This 30-
bp region, designated D1AS1, contains a sequence homologous to the AP-2 binding site …