Tc-99m-labeling of modified RNA
CS Hilger, MC Willis, M Wolters… - Nucleosides & …, 1999 - Taylor & Francis
CS Hilger, MC Willis, M Wolters, WA Pieken
Nucleosides & nucleotides, 1999•Taylor & FrancisThe synthesis of Tc-99m-labeled, modified RNA is reported. This new class of
radiopharmaceuticals is of potential interest as target specific imaging agents. The
preparation of N3S-RNA was achieved by coupling protected MAG2-units to amino modified
ON's. The N3S-RNA was Tc-99m-labeled with 90–95% radiochemical yield and specific
activities of 37MBq/nmol leading to 1: 1-Tc-99m-N3S-aptamers.
radiopharmaceuticals is of potential interest as target specific imaging agents. The
preparation of N3S-RNA was achieved by coupling protected MAG2-units to amino modified
ON's. The N3S-RNA was Tc-99m-labeled with 90–95% radiochemical yield and specific
activities of 37MBq/nmol leading to 1: 1-Tc-99m-N3S-aptamers.
Abstract
The synthesis of Tc-99m-labeled, modified RNA is reported. This new class of radiopharmaceuticals is of potential interest as target specific imaging agents. The preparation of N3S-RNA was achieved by coupling protected MAG2-units to amino modified ON's. The N3S-RNA was Tc-99m-labeled with 90–95% radiochemical yield and specific activities of 37MBq/nmol leading to 1:1-Tc-99m-N3S-aptamers.
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