Generating improved single-chain Fv molecules for tumor targeting
GP Adams, R Schier - Journal of immunological methods, 1999 - Elsevier
Due to their ease of isolation from phage display libraries and their ability to recognize
conserved antigens, single-chain Fv (scFv) molecules are rapidly becoming commonplace.
However, the monovalent nature of the scFv molecule often dictates, at best, transient
interactions with target antigens when molecules with moderate to low affinity are employed.
This, along with their rapid elimination from circulation, has limited the utility of scFv
molecules for applications in the fields of cancer imaging and therapy. Recently, a number of …
conserved antigens, single-chain Fv (scFv) molecules are rapidly becoming commonplace.
However, the monovalent nature of the scFv molecule often dictates, at best, transient
interactions with target antigens when molecules with moderate to low affinity are employed.
This, along with their rapid elimination from circulation, has limited the utility of scFv
molecules for applications in the fields of cancer imaging and therapy. Recently, a number of …