Proteolysis by presenilins and the renaissance of tau
C Haass, E Mandelkow - Trends in Cell Biology, 1999 - cell.com
C Haass, E Mandelkow
Trends in Cell Biology, 1999•cell.comA simple model for presenilins acting as aspartyl proteases with a-secretase activity. The PS
holoprotein (a) is autocatalytically activated by its own aspartyl protease activity (b). The
resulting fragments bind to each other (G. Thinakaran, Chicago, USA) and form the active-
secretase, which cleaves beta amyloid precursor protein (APP) within its transmembrane
domain (c).
holoprotein (a) is autocatalytically activated by its own aspartyl protease activity (b). The
resulting fragments bind to each other (G. Thinakaran, Chicago, USA) and form the active-
secretase, which cleaves beta amyloid precursor protein (APP) within its transmembrane
domain (c).
A simple model for presenilins acting as aspartyl proteases with a-secretase activity. The PS holoprotein (a) is autocatalytically activated by its own aspartyl protease activity (b). The resulting fragments bind to each other (G. Thinakaran, Chicago, USA) and form the active-secretase, which cleaves beta amyloid precursor protein (APP) within its transmembrane domain (c).
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