[HTML][HTML] Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1, 3-dipropylxanthine (CPX) and 1, 3-diallyl-8 …
8-Cyclopentyl-1, 3-dipropylxanthine (CPX) and 1, 3-diallyl-8-cyclohexylxanthine (DAX) are
xanthine adenosine antagonists which activate chloride efflux from cells expressing either
wild-type or mutant (ΔF508) cystic fibrosis transmembrane conductance regulator (CFTR).
These drugs are active in extremely low concentrations, suggesting their possible
therapeutic uses in treating cystic fibrosis. However, knowledge of the mechanism of action
of these compounds is lacking. We report here that the same low concentrations of both CPX …
xanthine adenosine antagonists which activate chloride efflux from cells expressing either
wild-type or mutant (ΔF508) cystic fibrosis transmembrane conductance regulator (CFTR).
These drugs are active in extremely low concentrations, suggesting their possible
therapeutic uses in treating cystic fibrosis. However, knowledge of the mechanism of action
of these compounds is lacking. We report here that the same low concentrations of both CPX …
