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ResearchIn-Press PreviewEndocrinologyOncology Open Access | 10.1172/JCI170809
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Lafront, C. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Germain, L. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Campolina-Silva, G. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Weidmann, C. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Berthiaume, L. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Hovington, H. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Brisson, H. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Jobin, C. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Frégeau-Proulx, L. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Cotau, R. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Gonthier, K. in: JCI | PubMed | Google Scholar |
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Lacouture, A. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Caron, P. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Ménard, C. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Atallah, C. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Riopel, J. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Latulippe, É. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Bergeron, A. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Toren, P. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Guillemette, C. in: JCI | PubMed | Google Scholar |
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Pelletier, M. in: JCI | PubMed | Google Scholar |
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Fradet, Y. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
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1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Pouliot, F. in: JCI | PubMed | Google Scholar
1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
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1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
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1Department of Molecular Medicine, Université Laval, Québec City, Canada
2Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec City, Canada
3Endocrinology and Nephrology Division, CHU de Québec-Université Laval Research Center, Québec City, Canada
4Cancer Research Center (CRC) of Université Laval, Québec City, Canada
5Department of Medicine, Université Laval, Québec City, Canada
6Department of Pathology, CHU de Québec-Université Laval, Québec City, Canada
7Department of Microbiology-Infectious Diseases and Immunology, Université Laval, Québec City, Canada
Find articles by Audet-Walsh, É. in: JCI | PubMed | Google Scholar |
Published April 16, 2024 - More info
Just as the androgen receptor (AR), the estrogen receptor α (ERα) is expressed in the prostate and is thought to influence prostate cancer (PCa) biology. Yet, the incomplete understanding of ERα functions in PCa hinders our ability to fully comprehend its clinical relevance and restricts the repurposing of estrogen-targeted therapies for the treatment of this disease. Using two human PCa tissue microarray cohorts, we first demonstrated that nuclear ERα expression was heterogeneous among patients, being only detected in half of tumors. Positive nuclear ERα levels were correlated with disease recurrence, progression to metastatic PCa, and patient survival. Using in vitro and in vivo models of the normal prostate and PCa, bulk and single-cell RNA-Seq analyses revealed that estrogens partially mimic the androgen transcriptional response and induce specific biological pathways linked to proliferation and metabolism. Bioenergetic flux assays and metabolomics confirmed the regulation of cancer metabolism by estrogens, supporting proliferation. Using cancer cell lines and patient-derived organoids, selective estrogen receptor modulators, a pure anti-estrogen, and genetic approaches impaired cancer cell proliferation and growth in an ERα-dependent manner. Overall, our study revealed that, when expressed, ERα functionally reprograms PCa metabolism, is associated with disease progression, and could be targeted for therapeutic purposes.